Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

Background & aimsTo investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses.MethodsIn a randomized crossover design, we compared duodenal (via nasoduodenal tube) parenteral (intravenous) over 180 min identical mixed meals concentrations in eight healthy lean men. We analysed responses two periods: intraprandial period from time point (T) 0 until T180 during postprandial T360, after discontinuation administration.ResultsIntravenous decreased (AUC (μmol/L∗min) 1469 ± 284 240 39, p < 0.01) response (985 223 5, 0.05) was accompanied by including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, 2 fibroblast growth factor 19. Furthermore, elicited greater glucose concentrations, but similar insulin to administration.ConclusionsCompared administration, nutrition results lower This higher face exposing clear incretin effect administration. The alterations homeostasis were apparent only one meal.